Commander Data from Star Trek: The Next Generation—Rommie possessed superhuman abilities, like super-strength and speed, heightened senses, and resistance to injury.
For the Boston-born Seamus Harper Gordon Michael Woolvett and other non-engineered humans like him, life under the Nietzscheans was unbearable, so Harper ran away and eventually ended up as a crewman for Beka Valentine's Eureka Maru.